Chargers vs. Colts: Week 7 Injury Report Breakdown and Analysis (2025)

Hold onto your helmets, football fans, because the Week 7 injury report for the Chargers vs. Colts matchup is here, and it’s a doozy! Six key players were limited in Wednesday’s practice, raising questions about their readiness for Sunday’s showdown at SoFi Stadium. But here’s where it gets controversial: while some absences are injury-related, others are listed as ‘rest,’ leaving fans and analysts alike scratching their heads. Is this a strategic move, or a sign of deeper concerns? Let’s dive in.

The Chargers’ first injury report of the week reveals a mix of setbacks and surprises. Five players sat out entirely: left tackle Joe Alt (ankle), right tackle Trey Pipkins III (knee), safety Elijah Molden (thumb), linebacker Troy Dye (thumb), and wide receiver Keenan Allen, who was held out for rest—not injury. Allen’s absence, though not injury-related, sparks debate: is this a precautionary measure, or a hint at managing his workload for the long haul? And this is the part most people miss: the offensive line’s health could be a game-changer, especially with Alt and Pipkins sidelined.

Meanwhile, six players were limited in practice, including star outside linebacker Khalil Mack (elbow), safety Derwin James, Jr. (rest/wrist), and linebacker Daiyan Henley (groin). Mack’s return to practice—his 21-day window opened Wednesday—is a bright spot, but his elbow injury raises questions about his effectiveness. James, meanwhile, was limited for rest, but his wrist issue could be a lingering concern. Wide receivers Quentin Johnston (hamstring) and Derius Davis (knee), along with offensive lineman Jamaree Salyer (knee), rounded out the limited group.

On the brighter side, linebacker Denzel Perryman (ankle), fullback/defensive tackle Scott Matlock (ankle), and outside linebacker Kyle Kennard (knee) were full participants. Perryman’s 21-day practice window opened last week, signaling his potential return to full strength. But here’s the kicker: with so many key players banged up, how will the Chargers’ depth hold up against the Colts?

Bold prediction: This game could hinge on the offensive line’s ability to protect Justin Herbert. Without Alt and Pipkins, the Chargers might struggle to keep the Colts’ pass rush at bay. But if Mack and James are even 80% healthy, the defense could still make life miserable for Indianapolis.

What do you think? Are the Chargers’ injuries a cause for alarm, or just part of the NFL grind? Is resting Keenan Allen a smart move, or a risky gamble? Let us know in the comments—this is one debate you won’t want to miss!

Chargers vs. Colts: Week 7 Injury Report Breakdown and Analysis (2025)

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